Advances in network dynamics of in vitro neural systems
Oleg Vinogradov | University of Tübingen, Germany
Paul Spitzner| Max Planck Institute for Dynamics and Self-Organization, Germany
In vitro cultures of neurons are one of the classical model systems in neuroscience that provide a great balance between complexity and experimental convenience. Due to this balance, in vitro cultures have supported the discovery of fundamental properties of neuronal networks, such as synaptic plasticity, E/I balance, and various homeostatic mechanisms. In recent years, major progress in experimental techniques and stem cells technologies has enabled greater control over the genetic and phenotypic heterogeneity of plated cells. Simultaneously, neuro-engineering and organoid technology allowed for unprecedented control over the topological structure of networks.
The goal of this workshop is to bring together experts in experiments, theory, and data analysis to explore insights into collective dynamics, network organization, and pathological pathways of complex neuropsychiatric disorders, which were enabled by recent advances in neural
models in vitro. We will also address ongoing experimental obstacles such as the variability of network dynamics between preparations, discuss recently discovered ways to enrich the complexity of network activity, and provide a perspective for future research that further closes the gap with in vivo systems.