Recent experiments have revealed ongoing changes in the brain. In particular, synapses show intrinsic dynamics, even in the absence of activity. They also appear and vanish over time leading to a dynamic connectome. On a higher level, representations of information by neural activity exhibit continuous change or drift. In contrast, memories and behavior often remain stable for a long time. This workshop aims to bridge the different levels of ongoing changes and to discuss how function can be maintained in their presence. Specifically, the workshop will explore the following questions. How can unstable and intrinsically dynamic synapses support stable memories? Are ongoing changes of synapses a cause of representational drift? What are the characteristics of representational drift in different brain systems? What roles do homeostasis and redundancy play? How are the ongoing changes related to disorders and aging of the brain?
The workshop will bring together experimental, computational and theoretical perspectives on these questions. In several talks, researchers will present recent experimental data demonstrating drift or stability of neural representations. Furthermore, modeling studies addressing different aspects of ongoing changes will showcase current computational and theoretical approaches. There will be time to interactively discuss questions and ideas among the participants. We hope the workshop will foster the exchange between the different perspectives and aid our conceptual understanding of a dynamic structure-function relationship in neuroscience.