Ready, set-point, go: Stability and change across neuronal scales

Organizers

Chaitanya Chintaluri  | Institute of Science and Technology, Austria
Lee Susman| Princeton University, USA
Maayan Levy | Institute of Science and Technology, Austria

Abstract

The biological machinery that sustains life operates under constantly changing conditions. Organisms must react to these changes to maintain homeostasis, or favorable operational conditions. Such ideal conditions, or set-points, are the valleys to which life gravitates. In this workshop we will delve into the cellular, circuit and system mechanisms which facilitate ‘living in the valley’ for the nervous system. In the nervous system, changes can occur across a wide range of spatial and temporal scales. For example, fluctuations in nutrient availability can rapidly alter neural response. The turnover rate of ion channels can change the firing patterns in a matter of hours. Similarly, behavioral states such as hunger can prompt feeding and sleep can modify network connectivity. At a higher level of abstraction, animals must also learn, retain memory, and plan across their lifespan. We will address how neurons, networks and the organism as a whole cope with change and build resilience in its anticipation. We will emphasize that neurons are more than computational units – they are living machines.

Schedule (CEST)

Tuesday, Sept 13

14:00

Introduction

14:10

Inna Slutsky| Tel Aviv University, Israel
Stability and Dynamics of Hippocampal Circuits

14:50

Chaitanya Chintaluri | Institute of Science and Technology, Austria
Action potentials that may serve metabolic homeostasis

15:20

Alon Rubin | Weizmann Institute of Science, Israel
Representational drift in hippocampus and cortex

15:50

Carolina Rezaval | University of Birmingham, UK
Neural mechanisms underlying the choice between food and sex

16:30

30 min break

17:00

Timothy O’Leary | University of Cambridge, UK
Homeostasis of neural codes

17:30

Round table discussion
All workshop speakers

18:30

End of first day

Wednesday, Sept 14

08:30

Friedemann Zenke | Friedrich Miescher Institute for Biomedical Research, Switzerland
Homeostatic plasticity in functional neural networks – Lessons from top-down and bottom-up modeling approaches

09:00

Daniel Levenstein | McGill University, Canada
The cortical firing rate distribution is maintained by sleep and reflects a heterogeneous neuronal ground state

09:30

Astrid Prinz | Emory University, USA
The role of parameter degeneracy and correlations in homeostasis

10:00

Lee Susman | Princeton University, USA
Stable memory with unstable synapses

10:30

30 min break

11:00

t.b.a.

11:40

Round table discussion
All workshop speakers

12:30

End