The inner life of dendrites – mechanisms behind synaptic input integration

Organizers

Fabio Sartori | Max Planck Institute for Brain Research, Frankfurt a.M., Germany
Surbhit Wagle | University of Bonn, Germany & Max Planck Institute for Brain Research, Frankfurt a.M., Germany
Tatjana Tchumatchenko | University of Bonn, Germany & Max Planck Institute for Brain Research, Frankfurt a.M., Germany

Abstract

Synapses are the fundamental units of information transmission in the brain. Maintenance and change in the synaptic efficacy require precise regulation of proteins and mRNAs in the synapses, dendrites, and axons. This is a challenge because the typical half-life of a protein is only a few days, while the time-scale of the behavior the proteins regulate ranges from few minutes to several decades.
This workshop aims to explain this gap in time scales by discussing the mechanisms that allow the neurons to regulate the availability of relevant proteins and mRNAs across the neuronal processes. The speakers in the workshop will cover topics ranging from mRNA and protein turnover to dendritic transport and relate them to neuronal computation.

Schedule (CEST)

14:00

Hye Yoon Park | Seoul National University, South Korea
Dendritic transport of mRNP follows an aging Lévy walk

14:30

Daniel Choquet | CNRS, Bordeaux University, France
Linking synapse nanoscale organization and function

15:00

Timothy O’Leary | University of Cambridge, UK
Hidden instabilities place limits on the responsiveness of synaptic scaling

15:30

15 min break

15:45

Mark van Rossum | University of Nottingham, UK
Energy considerations in learning and synaptic plasticity

16:15

Paul Bressloff | University of Utah, USA
A queuing model of axonal transport

16:45

Marina Mikhaylova | Humboldt-Universität zu Berlin, Germany
Synaptic control of organelle localisation: focus on the ER

17:15

15 min break

17:30

Anne-Sophie Hafner | Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands
AMPAR assembly and trafficking to synapses: the key role of auxiliary proteins

18:00

Ashley Bourke | Max Planck Institute for Brain Research, Frankfurt a.M., Germany
Live-cell imaging and computational modeling of activity-regulated receptor trafficking dynamics

18:30

45 min break

19:15

Noam Ziv | Technion, Haifa, Israel
Synaptic configuration instability and its possible consequences

19:45

Discussion

End