{"id":5866,"date":"2021-03-02T09:25:13","date_gmt":"2021-03-02T08:25:13","guid":{"rendered":"http:\/\/bernstein.mylapo.de\/heidelberg-mannheim\/"},"modified":"2024-03-12T10:04:17","modified_gmt":"2024-03-12T09:04:17","slug":"heidelberg-mannheim","status":"publish","type":"page","link":"https:\/\/bernstein-network.de\/en\/network\/bernstein-centers\/heidelberg-mannheim\/","title":{"rendered":"Heidelberg-Mannheim"},"content":{"rendered":"<div id='av_section_1'  class='avia-section av-3m0avy-ba3004e6bfb486c0cef0e77c412ed282 main_color avia-section-default avia-no-border-styling  avia-builder-el-0  el_before_av_section  avia-builder-el-first  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><main  class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-5866'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3fhfn2-a4e9d854292d8a6e2de0106f12133b20\">\n.flex_column.av-3fhfn2-a4e9d854292d8a6e2de0106f12133b20{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-3fhfn2-a4e9d854292d8a6e2de0106f12133b20 av_one_full  avia-builder-el-1  el_before_av_three_fifth  avia-builder-el-first  first flex_column_div av-zero-column-padding  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-36x7pj-efb32cdfc6945ff32ef2ac91d2d3586f\">\n#top .av-special-heading.av-36x7pj-efb32cdfc6945ff32ef2ac91d2d3586f{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-36x7pj-efb32cdfc6945ff32ef2ac91d2d3586f .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-36x7pj-efb32cdfc6945ff32ef2ac91d2d3586f .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-36x7pj-efb32cdfc6945ff32ef2ac91d2d3586f av-special-heading-h1 blockquote modern-quote  avia-builder-el-2  el_before_av_hr  avia-builder-el-first '><h1 class='av-special-heading-tag '  >Bernstein Center for Computational Neuroscience Heidelberg-Mannheim<\/h1><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-khnqxmhr-f005f3883bc28340180a25d2f926af5c\">\n#top .hr.av-khnqxmhr-f005f3883bc28340180a25d2f926af5c{\nmargin-top:0px;\nmargin-bottom:30px;\n}\n.hr.av-khnqxmhr-f005f3883bc28340180a25d2f926af5c .hr-inner{\nwidth:60px;\nborder-color:#004c93;\n}\n<\/style>\n<div  class='hr av-khnqxmhr-f005f3883bc28340180a25d2f926af5c hr-custom  avia-builder-el-3  el_after_av_heading  avia-builder-el-last  hr-left hr-icon-no'><span class='hr-inner inner-border-av-border-fat'><span class=\"hr-inner-style\"><\/span><\/span><\/div><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-37buyu-7e454dbe0c398e5d03f8ad3bbcbda56a\">\n.flex_column.av-37buyu-7e454dbe0c398e5d03f8ad3bbcbda56a{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-37buyu-7e454dbe0c398e5d03f8ad3bbcbda56a av_three_fifth  avia-builder-el-4  el_after_av_one_full  el_before_av_two_fifth  first flex_column_div av-zero-column-padding  column-top-margin'     ><p><section  class='av_textblock_section av-kd4n3qmj-d4300ddf304979d2676885ae5bbd2a13 '  ><div class='avia_textblock' ><p>The Bernstein Center Heidelberg-Mannheim investigates implications of genetic variations for neural information processing in psychiatric conditions.<\/p>\n<p>Recent years have seen a tremendous progress in identifying risk genes for a number of psychiatric conditions, but we mostly lack a mechanistic understanding of the causal and dynamical links between genetically determined neuronal properties, their implications for cortical network dynamics, and their impact in turn on behavior and cognition. However, such knowledge would be of tremendous clinical relevance.<\/p>\n<p>Computational models of neuronal systems are an excellent tool to study such causal links. The ultimate goal of the Bernstein Center Heidelberg-Mannheim is to derive an explanatory and theoretical framework for linking genetic conditions to higher cognitive function and its aberrations in schizophrenia, depression, and age-related mental decline.<\/p>\n<p>To these ends, biologically detailed models of relevant brain structures as well as their connection to intracellular processes on the one hand and to macroscopic brain dynamics (fMRI, EEG) on the other hand, will be developed. In close exchange with experimental studies on different levels (genes, intracellular processes, network physiology, fMRI\/EEG-measurements, behavior) these models will be parameterized, validated, and their predictions tested. Translation into clinical application is sought through novel diagnostic predictors and a computational platform for an \u2018in-silico psychopharmacology\u2019. In Heidelberg the more cellular and network-physiological aspects of the proposal will be pursued, while work at the Central Institute of Mental Health in Mannheim will focus more on the psychiatric, human, and applicational aspects.<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-ko9r9vwf-8312ebb504e6b73d726a2b03adb73ca0\">\n#top .hr.hr-invisible.av-ko9r9vwf-8312ebb504e6b73d726a2b03adb73ca0{\nheight:25px;\n}\n<\/style>\n<div  class='hr av-ko9r9vwf-8312ebb504e6b73d726a2b03adb73ca0 hr-invisible  avia-builder-el-6  el_after_av_textblock  el_before_av_button '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<div  class='avia-button-wrap av-khp3rft8-bbf8f915dd0337bfc5426fd9a01c7e7e-wrap avia-button-left  avia-builder-el-7  el_after_av_hr  avia-builder-el-last '><a href='http:\/\/www.bccn-heidelberg-mannheim.de'  class='avia-button av-khp3rft8-bbf8f915dd0337bfc5426fd9a01c7e7e av-link-btn avia-icon_select-no avia-size-large avia-position-left avia-color-theme-color'  target=\"_blank\"  rel=\"noopener noreferrer\"  aria-label=\"Website of the Bernstein Center\"><span class='avia_iconbox_title' >Website of the Bernstein Center<\/span><\/a><\/div><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-37buyu-2-0fd7657af16b19abddc00ab0be2f19aa\">\n.flex_column.av-37buyu-2-0fd7657af16b19abddc00ab0be2f19aa{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-37buyu-2-0fd7657af16b19abddc00ab0be2f19aa av_two_fifth  avia-builder-el-8  el_after_av_three_fifth  avia-builder-el-last  flex_column_div av-zero-column-padding  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-260wyc-53dacbecdaf08c8a48ac0c19962b6462\">\n.avia-image-container.av-260wyc-53dacbecdaf08c8a48ac0c19962b6462 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-260wyc-53dacbecdaf08c8a48ac0c19962b6462 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-260wyc-53dacbecdaf08c8a48ac0c19962b6462 av-styling-no-styling avia-align-center  avia-builder-el-9  el_before_av_image  avia-builder-el-first '  ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-8357 avia-img-lazy-loading-not-8357 avia_image ' src=\"https:\/\/bernstein-network.de\/wp-content\/uploads\/2021\/05\/Mannheim.jpg\" alt='Mannheim' title='Mannheim'  height=\"1666\" width=\"2500\" srcset=\"https:\/\/bernstein-network.de\/wp-content\/uploads\/2021\/05\/Mannheim.jpg 2500w, https:\/\/bernstein-network.de\/wp-content\/uploads\/2021\/05\/Mannheim-300x200.jpg 300w, https:\/\/bernstein-network.de\/wp-content\/uploads\/2021\/05\/Mannheim-1030x686.jpg 1030w, https:\/\/bernstein-network.de\/wp-content\/uploads\/2021\/05\/Mannheim-768x512.jpg 768w, https:\/\/bernstein-network.de\/wp-content\/uploads\/2021\/05\/Mannheim-1536x1024.jpg 1536w, https:\/\/bernstein-network.de\/wp-content\/uploads\/2021\/05\/Mannheim-2048x1365.jpg 2048w, https:\/\/bernstein-network.de\/wp-content\/uploads\/2021\/05\/Mannheim-1500x1000.jpg 1500w, https:\/\/bernstein-network.de\/wp-content\/uploads\/2021\/05\/Mannheim-705x470.jpg 705w\" sizes=\"(max-width: 2500px) 100vw, 2500px\" \/><\/div><\/div><\/div><br \/>\n<\/p><\/div>\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><div id='bernstein-conference'  class='avia-section av-17qujn-e43df4d15f0a052fabe1b5fea4db469b alternate_color avia-section-large avia-no-border-styling  avia-builder-el-11  el_after_av_section  avia-builder-el-last  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-5866'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-13pc4b-11f2e811b389e9670bbd27d526db4316\">\n.flex_column.av-13pc4b-11f2e811b389e9670bbd27d526db4316{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-13pc4b-11f2e811b389e9670bbd27d526db4316 av_one_half  avia-builder-el-12  el_before_av_one_half  avia-builder-el-first  first flex_column_div av-zero-column-padding  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-kpcgxmxl-739c6af0fa0cf4cbc88331ccc0944575\">\n#top .av-special-heading.av-kpcgxmxl-739c6af0fa0cf4cbc88331ccc0944575{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-kpcgxmxl-739c6af0fa0cf4cbc88331ccc0944575 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-kpcgxmxl-739c6af0fa0cf4cbc88331ccc0944575 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-kpcgxmxl-739c6af0fa0cf4cbc88331ccc0944575 av-special-heading-h3 blockquote modern-quote  avia-builder-el-13  el_before_av_textblock  avia-builder-el-first '><h3 class='av-special-heading-tag '  >Coordinator<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-kd0arlij-10bd5d6cb4509b9fee2b7124d30412ff '  ><div class='avia_textblock' ><p>Prof. Dr. Daniel Durstewitz<br \/>\nZentralinstitut f\u00fcr Seelische Gesundheit<br \/>\nJ5<br \/>\nD-68159 Mannheim<br \/>\n+49 621 1703-2361<br \/>\n+49 621 1703-2005<br \/>\n<a href=\"mailto:daniel.durstewitz@zi-mannheim.de\">daniel.durstewitz@zi-mannheim.de<\/a><\/p>\n<\/div><\/section><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" 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